Statistics · sourced · updated November 2026

Medication Adherence Statistics: how often medicines are not taken as prescribed

The figures most often quoted on medication non-adherence in the U.S., with where each one comes from.

~50%

of medications for chronic disease are not taken as prescribed.

Source: Review in Annals of Internal Medicine, as reported by Becker’s Hospital Review

20%–30%

of prescriptions are never filled.

Source: Annals of Internal Medicine review, via Becker’s

~125,000

deaths a year in the U.S. are estimated to be linked to non-adherence, along with at least 10% of hospitalizations.

Source: Becker’s Hospital Review summary of published estimates

$100B–$289B

estimated yearly cost of non-adherence to the U.S. health system.

Source: Becker’s Hospital Review summary of published estimates

41%

of heart attack patients do not take their blood pressure medicines; about 33% of kidney transplant patients miss anti-rejection medicines.

Source: Becker’s Hospital Review

What it means

Most non-adherence comes from ordinary friction — forgetting, confusing schedules, running out. Simple records and refill warnings address the most common causes.

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Journalists, students and bloggers are welcome to use these figures. Please cite the original source for each number, and link here if this roundup helped:

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